Beta -Catenin兔單克隆抗體

價格￥1000
規(guī)格100ul
貨號HKZ150304
單位支
品牌HaoKebio

產(chǎn)品介紹

產(chǎn)品參數(shù)

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品牌	商品編碼	商品名稱	規(guī)格	單位	單價
HaoKebio	HKZ150304	Beta -Catenin兔單克隆抗體	100ul	支	1000

Beta-Catenin
Recombinant?Rabbit?Monoclonal Antibody?Product?Datasheet
Catalog# ?BX50181?Clone# ?BP6159
Predicted?Molecular Wt:
86kDa
Purity: ??ProA?affinity?purified?IgG
Species Cross-reactivity:
Human
Form: ??Liquid
Applications:
IHC-P
Swissprot?ID: ??P35222
Background:
Beta-Catenin?is a?key?regulatory?protein?in Wnt signaling,a?pathway that transmits signals?from?the?cytoplasm?to?the?nucleus,?turning on the expression of specific?genes?in?the?nucleus.Under?normal?conditions,?Beta-Catenin?exists?mainly?in?the?cell
membrane of?normal cells, and gene?mutations?lead to?accumulation?in?the?nucleus.?At?present,?Beta-Catenin?gene?mutation?has?been found?in various tumors, such as colon?cancer,?lung?cancer,?prostate?cancer,?esophageal?cancer,?breast?cancer,?ovarian
cancer, endometrial cancer,familial adenomatous?polyposis, solid?pseudopapilloma?of?pancreas,?etc.?High?levels?of?nucleus
positivityare seen?in desmoid fibromatosis,?isolated fibrous tumors, synovial?sarcomas?and?endometrial?stromal?sarcomas,?and?carcinosarcomas.?It?is?mainly?used for the diagnosis,?invasion and?metastasis of?malignant tumor.
Subcellular?location:
Membrane?&?Cytoplasm?&?Nucleus
Recommended?method:
Heat?induced epitope?retrieval with Tris-EDTA?buffer???(pH?9.0),?primary?antibody?incubate?at?RT?(18°C-25°C)?for?30?minutes.
Immunogen:
Synthetic?peptide corresponding to?Human?Beta-?Catenin was?used as an?immunogen. The?exact
sequence?is?proprietary.
Storage?Buffer:
PBS?59%, Sodium?azide?0.01%,?Glycerol?40%,?BSA 0.05%.
Storage conditions:
-25°C?to?-18°C
Storage instructions:
Shipped on?blue?ice.?Upon delivery,?aliquot,?and?store?at?-25°C?to?-18°C. Avoid?freeze?/?thaw?cycles.
Recommended?Dilutions:
IHC-P:?????1:100-1:200
Background?References:
1. ?Li?XG??et?al. Toxicol?Lett?305:19-31?(2019).
2.?Xu?H??etal. Oncol?Rep?41:1180-1188?(2019).Immunohistochemistry?(Formalin/PFA-fixed
paraffin-embedded?sections?analysis?of
human??prostate ?tissue
labelling?Beta-Catenin?with?BP6159.?Heat?mediated
antigen?retrieval was
performed?using Tris/EDTA
buffer?pH?9.0

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